منابع مشابه
NOTCH mutations: multiple faces in human malignancies.
NOTCH proteins have been implicated in multiple cellular functions, such as stem cell maintenance and cell fate determination. Initially identified as proto-oncogenes because they promote the development of certain types of leukemia, inactivating mutations of NOTCH were later reported. Together with the potential distinct functions of NOTCH family members, their ligands and associated niches, t...
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Narcissism, being the critical part of the toxic leadership paradigm,has its own impact in the education sphere. Contrastingly,leader’s narcissism cannot be simply underweighted because suchleaders often tend to be creative strategists who can take riskychallenges to suffice the self-ego and leave behind a legacy aswell. This commentary intends to portray the complex mosaic ofthe positive and n...
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BACKGROUND Mutations in BRAF were first reported in 2002. Since that time, the molecular basis for oncogenic signaling has been elucidated in multiple malignancies. The development of v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors has helped improve clinical outcomes in malignant melanoma and is suggested by case reports in other malignancies. METHODS A review of pertinent ar...
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A newly cloned gene named wild-type p53-activated fragment 1 (WAF1; also known as p21, Pic-1, Cip-1, or SDI1) is directly regulated by p53 and can itself suppress tumor cell growth in culture. Induction of expression of WAF1 may be an important means by which cells with DNA injury arrest their growth to repair DNA or undergo apoptosis. Based on the hypothesis that mutations of this gene may pla...
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Chromatin structure regulating processes mediated by the adenosine triphosphate (ATP) - dependent chromatin remodeling complex and the covalent histone-modifying complexes are critical to gene transcriptional control and normal cellular processes, including cell stemness, differentiation, and proliferation. Gene mutations, structural abnormalities, and epigenetic modifications that lead to aber...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2015
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-15-0063